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Project Dissertation

My research goal is focused on neuroanatomy. The aim is to transfer modern chemical fixation technology to electron microscopy. As a result, we visualize cellular structure at the highest magnification and localize proteins in neuron synapses with the utmost accuracy. My current results show that the fine structure is preserved at the highest standards and that the sensitivity of protein localization is improved at the same time.

Research Experience

Glyoxal fixation for modern electron microscopy and immunogold protein localization.

2018 - Present

As a graduate student, I optimized a technique to advance the sensitivity of immunogold localization of proteins for electron microscopy. The increase in labeling intensity will make it possible to determine the copy number of individual synaptic components in neurons. 

 

Presentations 

  • Jailenne I. Quiñones-Rodríguez and Thomas Schikorski (2021) Glyoxal modern fixation for light and electron microscopy. Puerto Rico Neuroscience Meeting. San Juan, PR.  

  • Jailenne I. Quiñones-Rodríguez and Thomas Schikorski (2021) The First Non-Cancerogenic Fixative for Modern Chemical Fixation in Electron and Light Microscopy. Puerto Rico Southeast IDeA Regional Meeting. San Juan, PR. 

  • Jailenne I. Quiñones-Rodríguez (2021) Glyoxal a nontoxic substitute to achieve superior preservation for modern electron microscopy. Fundación Garcia Rinaldi. Universidad Central del Caribe.

  • Jailenne I. Quiñones-Rodríguez and Thomas Schikorski (2019) Glyoxal, a potent substitute for paraformaldehyde/glutaraldehyde fixation in modern electron microscopy. American Society for Cell Biology. Washington, DC. 

  • Jailenne I. Quiñones-Rodríguez and Thomas Schikorski (2019) Glyoxal, a potent substitute for paraformaldehyde/glutaraldehyde fixation in modern electron microscopy. Southeast IDeA Regional Meeting. Louisville, KY. 

  • Jailenne I. Quiñones-Rodríguez (2019) Glyoxal: A potential polyvalent substitute for paraformaldehyde in modern electron microscopy. Breaking Barriers through Collaboration. Universidad Central del Caribe. 

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Anatomical variations, and the significance of these findings in order to minimize surgical mortality and morbidity.

2015 - Present

I am currently working on different anatomical variations found during routine dissection. Knowledge of the variability in human morphology is crucial to improve diagnostic and interventional performance especially against the background of contemporary imaging techniques, open and laparoscopic surgery. 

Presentations 

  • Jailenne I. Quiñones-Rodríguez, Michael Velez-Crespo, and Sofia Jiménez-Dietsch (2021) An innovative anatomy outreach program for improving the first-year transition of medical students in Puerto Rico. American Association for Anatomy Virtual Regional Meeting. Arkansas, US.  

  • Jailenne I. Quiñones-Rodríguez, Michael Velez-Crespo, and Sofia Jiménez-Dietsch (2021) The importance of peer mentoring in gross anatomy laboratory: An approach for improving medical education in Puerto Rico. Anatomical Society Virtual Meeting. Glasgow, Australia. 

  • Jailenne I. Quiñones-Rodríguez and Natalia Y. Cárdenas-Suárez (2021) Mastering Anatomical Techniques program: An innovative teaching strategy for medical students. Molecular Biology Summer Academy. Universidad Central del Caribe.

  • Jailenne I. Quiñones-Rodríguez (2021) The relevance of clinical anatomy in medical education. Fundación Garcia Rinaldi. Universidad Central del Caribe.

  • Jailenne I. Quiñones-Rodríguez (2018) Anatomical dissection as a teaching method in medical school. Molecular Biology Summer Academy. Universidad Central del Caribe. 

  • Jailenne I. Quiñones-Rodríguez (2016) Highlighting human dissection through different regions. Molecular Biology Summer Academy. Universidad Central del Caribe. 

  • Jailenne I. Quiñones-Rodríguez (2016) The importance of human anatomical dissection in medical training. Fundación García Rinaldi, Universidad Central del Caribe. 

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Use of CaS Nanoparticles and Cancer Treatment.

2015 - 2013

As an undergraduate student, in collaboration with the UPR-PRISE program. I had the opportunity to work with other classmates to optimize and evaluate the use of CaS nanoparticles and breast cancer.

Presentations 

  • Nestor Carrasco, Carlos Ortiz, Jailenne Quiñones, Geishamarie Feliciano, Angel Ortiz, Daniel Rivera, Miguel Castro, Edu Suarez. (2014) Use of Levitated Cells n3D BiOAssay System to Determine Cytotoxicity of Calcium Sulfide (CaS) Clusters in Malignant Cells as Potential Cancer Cell Targeted Therapy (LB583), Journal, The FASEB Journal, Volume 28 (1) Pages LB583. https://doi.org/10.1096/fasebj.28.1_supplement.lb583

  • Michael Manoharan-Valerio, Carlos Ortiz, Jailenne Quiñones, Geishamarie Feliciano, Angel Díaz, Daniel Rivera, Miguel Castro, Edu Suarez. (2014) Determination of the IC50 and LD50 of Calcium Sulfide (CaS) Clusters on Malignant Carcinoma and Normal Fibroblasts Cell Lines (LB580). The FASEB Journal Volume 28 Issue 1 LB580. https://doi.org/10.1096/fasebj.28.1_supplement.lb580

Development of Carbon Nanotube-Based Sensor for the Detection of Myoglobin in Aqueous Solution.

2012

As an undergraduate student, in collaboration with UPR-Mayaguez. I had the opportunity to work with other classmates to develop a sensor to detect myoglobin in aqueous solutions.